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Production of tumor necrosis factor by human macrophages may be induced in vitro by cytoadherent and noncytoadherent strains of Plasmodium falciparum, with an optimal ratio of one to three parasitized erythrocytes per macrophage. Centrifuged and heated crude culture supernatants have the same effect, thus showing the existence of a thermostable soluble factor able to induce this expression. In vitro kinetic experiments have shown that the secretion of tumor necrosis factor appears early, with a maximal peak at 8 h.

Type

Journal article

Journal

Infect Immun

Publication Date

01/1990

Volume

58

Pages

214 - 216

Keywords

Animals, Erythrocytes, Immunity, Cellular, In Vitro Techniques, Macrophages, Plasmodium falciparum, Tumor Necrosis Factor-alpha