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Despite the existence of several three-dimensional structures of cytochrome c oxidases, a detailed understanding of pathways involved in proton movements through the complex remains largely elusive. Next to the two well-established pathways (termed D and K), an additional proton-conducting network ('H-channel') has been proposed for the beef heart enzyme. Yet, our recent mutational studies on corresponding residues of the Paracoccus denitrificans cytochrome c oxidase provide no clues that such a pathway operates in the prokaryotic enzyme.

Original publication

DOI

10.1042/BST0330829

Type

Journal article

Journal

Biochem Soc Trans

Publication Date

08/2005

Volume

33

Pages

829 - 831

Keywords

Bacterial Proteins, Biological Transport, Electron Transport Complex IV, Hydrogen, Ion Channels, Protons, Pseudomonas