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The ParMRC plasmid partitioning apparatus is one of the best characterized systems for bacterial DNA segregation. Bundles of actin-like filaments are used to push plasmids to opposite poles of the cell, whereupon they are stably inherited on cell division. This plasmid-encoded system comprises just three components: an actin-like protein, ParM, a DNA-binding adaptor protein, ParR, and a centromere-like region, parC. The properties and interactions of these components have been finely tuned to enable ParM filaments to search the cell space for plasmids and then move ParR-parC-bound DNA molecules apart. In this Review, we look at some of the most exciting questions in the field concerning the exact molecular mechanisms by which the components of this self-contained system modulate one another's activity to achieve bipolar DNA segregation.

Original publication

DOI

10.1038/nrmicro2425

Type

Journal article

Journal

Nat Rev Microbiol

Publication Date

10/2010

Volume

8

Pages

683 - 692

Keywords

Actins, Bacteria, DNA, Bacterial, Escherichia coli Proteins, Models, Molecular, Plasmids, Protein Binding