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The structure of foot-and-mouth disease virus has been determined at close to atomic resolution by X-ray diffraction without experimental phase information. The virus shows similarities with other picornaviruses but also several unique features. The canyon or pit found in other picornaviruses is absent; this has important implications for cell attachment. The most immunogenic portion of the capsid, which acts as a potent peptide vaccine, forms a disordered protrusion on the virus surface.

Original publication

DOI

10.1038/337709a0

Type

Journal article

Journal

Nature

Publication Date

23/02/1989

Volume

337

Pages

709 - 716

Keywords

Algorithms, Amino Acid Sequence, Aphthovirus, Biological Evolution, Capsid, Computer Simulation, Molecular Sequence Data, Picornaviridae, Viral Proteins, Viral Vaccines, X-Ray Diffraction