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When investigating the change in a biomarker, it is often believed that at least two measurements are needed from each participant, and that those with only one measurement should be excluded. In this short note, we explain why this could lead to imprecise and biased estimates. Furthermore, we discuss a standard statistical method that handles such issues.

Original publication

DOI

10.1093/qjmed/hcn099

Type

Journal article

Journal

QJM

Publication Date

10/2008

Volume

101

Pages

821 - 824

Keywords

Bias, Biomarkers, Computer Simulation, Data Interpretation, Statistical, Humans, Models, Statistical