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A monoclonal hybridoma antibody specific for platelet glycoprotein I complex is described. The nature od the antigen was determined by demonstration that it was chymotrypsin sensitive and gave a peak at 150 000 daltons on SDS-PAGE after immunoprecipitation. The expression of the antigen is restricted to platelets and megakaryocytes with at least 1.6 x 10(4) molecules of antigen per platelet. The antibody failed to bind to platelets from patients with Bernard Soulier syndrome, where there is known to be a deficiency of glycoprotein Ib/Is expression. Binding to platelets from patients with Glanzmann's thrombasthenia was normal.

Type

Journal article

Journal

Br J Haematol

Publication Date

12/1981

Volume

49

Pages

501 - 509

Keywords

Animals, Antibodies, Monoclonal, Antibody Specificity, Antigen-Antibody Reactions, Antigens, Blood Platelet Disorders, Blood Platelets, Glycoproteins, Humans, Membrane Proteins, Mice, Platelet Membrane Glycoproteins, Precipitin Tests, Tissue Distribution