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One hundred and twenty years ago, the Italian malariologists Marchiafava and Bignami proposed that the fundamental pathological process underlying lethal falciparum malaria was microvascular obstruction. Since then, several alternative hypotheses have been proposed. These formed the basis for adjunctive interventions, which have either been ineffective or harmful. Recent evidence strongly suggests that Marchiafava and Bignami were right.

Original publication

DOI

10.1093/infdis/jit116

Type

Journal article

Journal

J Infect Dis

Publication Date

15/07/2013

Volume

208

Pages

192 - 198

Keywords

P. falciparum, cerebral malaria, malaria, pathology, Animals, Antimalarials, Humans, Malaria, Microvessels, Plasmodium falciparum