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The within-outbreak diversity of hepatitis E virus (HEV) was studied during the outbreak of hepatitis E that occurred in Sudan in 2004. Specimens were collected from internally displaced persons living in a Sudanese refugee camp and two camps implanted in Chad. A comparison of the sequences in the ORF2 region of 23 Sudanese isolates and five HEV samples from the two Chadian camps displayed a high similarity (>99.7%) to strains belonging to Genotype 1. But four isolates collected in one of the Chadian camps were close to Genotype 2. Circulation of divergent strains argues for possible multiple sources of infection.

Original publication

DOI

10.1002/jmv.20487

Type

Journal article

Journal

J Med Virol

Publication Date

12/2005

Volume

77

Pages

519 - 521

Keywords

Chad, Gene Amplification, Genetic Heterogeneity, Genome, Viral, Genotype, Hepatitis E, Hepatitis E virus, Humans, Phylogeny, Reverse Transcriptase Polymerase Chain Reaction, Sequence Analysis, Sudan