Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Transgenic mice have been constructed expressing high (CD45RABC) and low (CD45R0) molecular weight CD45 isoforms on a CD45-/- background. Phenotypic analysis and in vivo challenge of these mice with influenza and lymphocytic choriomeningitis viruses shows that T cell differentiation and peripheral T cell function are related to the level of CD45 expression but not to which CD45 isoform is expressed. In contrast, B cell differentiation is not restored, irrespective of the level of expression of a single isoform. All CD45 trangenic mice have T cells with an activated phenotype and increased T cell turnover. These effects are more prominent in CD8 than CD4 cells. The transgenic mice share several properties with humans expressing variant CD45 alleles and provide a model to understand immune function in variant individuals.

Original publication

DOI

10.1093/intimm/dxh135

Type

Journal article

Journal

Int Immunol

Publication Date

09/2004

Volume

16

Pages

1323 - 1332

Keywords

Animals, B-Lymphocytes, Immunophenotyping, Leukocyte Common Antigens, Lymphocytic choriomeningitis virus, Mice, Mice, Inbred C57BL, Mice, Inbred DBA, Mice, Transgenic, Orthomyxoviridae, Protein Isoforms, T-Lymphocytes