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Controlled human malaria infection by blood stage parasite (BSP) inoculation is an alternative to the well-established model of infection with Plasmodium falciparum sporozoites delivered by mosquito bites. The BSP model has been utilized less frequently, but its use is increasing. Advantages of BSP challenge include greater ease of administration, better standardization of the infecting dose per volunteer, and good inter-study reproducibility of in vivo parasite dynamics. Recently, a surprising reduction in clinical symptoms at microscopic patency in the BSP model has been identified, which has an undefined and intriguing pathophysiologic basis, but may make this approach more acceptable to volunteers. We summarize clinical, parasitologic, and immunologic data from all BSP challenges to date, explore differences between the BSP and sporozoite models, and propose future applications for BSP challenge.

Original publication

DOI

10.4269/ajtmh.2012.11-0504

Type

Journal article

Journal

Am J Trop Med Hyg

Publication Date

04/2012

Volume

86

Pages

561 - 565

Keywords

Animals, Anopheles, Humans, Insect Bites and Stings, Malaria Vaccines, Malaria, Falciparum, Plasmodium falciparum, Sporozoites