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A major susceptibility locus for leprosy has recently been mapped on chromosome 10 (10p13) by genome-wide linkage analysis. Microsatellite markers from this genome screen that showed suggestive evidence of linkage to leprosy were evaluated in an additional 140 families with affected sib pairs. A second region of linkage has thus been identified on chromosome 20 (20p12). The peak of linkage lies at marker D20S115, which has a significant single-point maximum logarithm of odds score of 3.48 (P=.00003). Transmission disequilibrium testing of the microsatellite markers in 20p12 showed that the marker D20S835 is associated with protection against leprosy (P=.021), which suggests that a locus controlling susceptibility lies close to this marker.

Original publication

DOI

10.1086/343806

Type

Journal article

Journal

J Infect Dis

Publication Date

15/10/2002

Volume

186

Pages

1190 - 1193

Keywords

Chromosome Mapping, Chromosomes, Human, Pair 20, Female, Genetic Markers, Genetic Predisposition to Disease, Genetics, Population, Humans, India, Leprosy, Male, Microsatellite Repeats, Mycobacterium leprae