Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Methods for the identification and selection of patients (cases) with severe or very severe pneumonia and controls for the Pneumonia Etiology Research for Child Health (PERCH) project were needed. Issues considered include eligibility criteria and sampling strategies, whether to enroll hospital or community controls, whether to exclude controls with upper respiratory tract infection (URTI) or nonsevere pneumonia, and matching criteria, among others. PERCH ultimately decided to enroll community controls and an additional human immunodeficiency virus (HIV)-infected control group at high HIV-prevalence sites matched on age and enrollment date of cases; controls with symptoms of URTI or nonsevere pneumonia will not be excluded. Systematic sampling of cases (when necessary) and random sampling of controls will be implemented. For each issue, we present the options that were considered, the advantages and disadvantages of each, the rationale for the methods selected for PERCH, and remaining implications and limitations.

Original publication

DOI

10.1093/cid/cir1066

Type

Journal article

Journal

Clin Infect Dis

Publication Date

04/2012

Volume

54 Suppl 2

Pages

S117 - S123

Keywords

Bias, Case-Control Studies, Child Welfare, Child, Hospitalized, Child, Preschool, Epidemiologic Research Design, HIV Infections, Humans, Infant, Patient Selection, Pneumonia, Prevalence, Respiratory Tract Infections