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The constancy of strain genotypes of multiple isolates of Burkholderia pseudomallei from 13 patients with melioidosis was examined by BamHI ribotyping and pulsed-field gel electrophoresis (PFGE) of XbaI digests of DNA. Seven of 8 patients with single episodes of melioidosis each yielded genetically identical isolates and only one of five patients with recurrent episodes was infected with a new strain clearly distinct from the original primary strain. Variation was observed in PFGE patterns of primary and relapse isolates of another patient but this was insufficient to define genetically distinct strains. We conclude that most patients with single or multiple episodes of melioidosis retain a single strain.

Type

Journal article

Journal

Trop Med Int Health

Publication Date

07/1998

Volume

3

Pages

518 - 521

Keywords

Burkholderia pseudomallei, Electrophoresis, Gel, Pulsed-Field, Genotype, Humans, Melioidosis, RNA, Bacterial, RNA, Ribosomal, Recurrence, Restriction Mapping, Serotyping