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Simian immunodeficiency virus (SIV) is closely related to human immunodeficiency virus (HIV), their matrix antigens (MAs) sharing some 50% sequence identity. MA is a component of Pr55Gag, the sole protein required for assembly of the virion shell. MA targets Pr55 to the plasma membrane, and facilitates incorporation of the virus envelope protein and assembly of the Pr55Gag shell. Cleavage of Pr55 by the viral protease produces the mature protein of relative molecular mass 17-18K, which underlies the host-derived membrane and is important in both virus entry and nuclear localization of the virion core. Here we report the crystal structure of SIV MA. The molecule forms a trimer consistent with oligomerization in vitro, the observed virion architecture, and various biological properties of MA.

Original publication

DOI

10.1038/378743a0

Type

Journal article

Journal

Nature

Publication Date

14/12/1995

Volume

378

Pages

743 - 747

Keywords

Amino Acid Sequence, Antigens, Viral, Computer Graphics, Crystallography, X-Ray, Gene Products, gag, Models, Molecular, Molecular Sequence Data, Protein Conformation, Simian Immunodeficiency Virus, Viral Matrix Proteins, Virus Replication