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The proteasome is the most complex eukaryotic macromolecular assembly yet seen in fine detail. The structure reveals completely unexpected mechanisms by which the proteasome neatly chops up unwanted proteins for disposal or display to the immune system.

Original publication

DOI

10.1038/386437a0

Type

Journal article

Journal

Nature

Publication Date

03/04/1997

Volume

386

Pages

437 - 438

Keywords

Archaea, Binding Sites, Cysteine Endopeptidases, Molecular Structure, Multienzyme Complexes, Proteasome Endopeptidase Complex, Protein Conformation, Proteins, Saccharomyces cerevisiae