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Structural studies of foot-and-mouth disease virus (FMDV) have largely focused on the mature viral particle, providing atomic resolution images of the spherical protein capsid for a number of sero- and sub-types, structures of the highly immunogenic surface loop, Fab and GAG receptor complexes. Additionally, structures are available for a few non-structural proteins. The chapter reviews our current structural knowledge and its impact on our understanding of the virus life cycle proceeding from the mature virus through immune evasion/inactivation, cell-receptor binding and replication and alludes to future structural targets.

Type

Journal article

Journal

Curr Top Microbiol Immunol

Publication Date

2005

Volume

288

Pages

71 - 101

Keywords

Capsid Proteins, Foot-and-Mouth Disease Virus, Genome, Viral, Heparan Sulfate Proteoglycans, Integrins, Receptors, Virus, Viral Nonstructural Proteins, Virus Assembly