Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Adenovirus vectors with E1 deleted of the human serotype 5 (AdHu5) and the chimpanzee serotype 68 (AdC68) expressing the glycoprotein of the Evelyn Rokiniki Abelseth strain of rabies virus were tested upon oral application for induction of systemic and mucosal transgene product-specific antibody responses in mice. Both vectors induced systemic and mucosal antibodies to rabies virus, including virus-neutralizing antibodies and protection against a severe intracerebral challenge with a mouse-adapted strain of rabies virus. Pre-existing immunity of AdHu5 virus, which dampens induction of transgene product-specific immunity elicited by AdHu5 vectors given systemically did not impair the response induced by oral vaccination. Oral priming-boosting regimens with either heterologous or homologous adenoviral vectors used sequentially increased both mucosal and systemic antibody titers to rabies virus [corrected]

Original publication

DOI

10.1128/jvi.77.20.10780-10789.2003

Type

Journal article

Journal

J Virol

Publication Date

10/2003

Volume

77

Pages

10780 - 10789

Keywords

Adenoviridae, Administration, Oral, Animals, Antibodies, Viral, Female, Genetic Vectors, Mice, Mice, Inbred C57BL, Mice, Inbred ICR, Neutralization Tests, Rabies Vaccines, Transgenes, Vaccination, Vaccines, Synthetic