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By using a sensitive new assay, the terminal elimination half-life of the antimalarial piperaquine in a healthy volunteer was estimated to be 33 days, which is longer than estimated previously. This result illustrates the importance of extended sampling duration and sensitive assay methodologies in characterizing the disposition of slowly eliminated antimalarial drugs.

Original publication

DOI

10.1128/AAC.49.12.5127-5128.2005

Type

Journal article

Journal

Antimicrob Agents Chemother

Publication Date

12/2005

Volume

49

Pages

5127 - 5128

Keywords

Animals, Antimalarials, Half-Life, Humans, Quinolines, Sensitivity and Specificity