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P.berghei ANKA infection in CBA or CB57BL/6 mice is used widely as a murine 'model' of human cerebral malaria (HCM), despite markedly different histopathological features. The pathology of the murine model is characterised by marked inflammation with little or no intracerebral sequestration of parasitised erythrocytes, whereas HCM is associated with intense intracerebral sequestration, often with little inflammatory response. There are now more than ten times as many studies each year of the murine model than on HCM. Of 48 adjunctive interventions evaluated in the murine model, 44 (92%) were successful, compared with only 1 (6%) of 17 evaluated in HCM during the same period. The value of the mouse model in identifying pathological processes or therapeutic interventions in human cerebral malaria is questionable.

Original publication

DOI

10.1016/j.pt.2009.10.007

Type

Journal article

Journal

Trends Parasitol

Publication Date

01/2010

Volume

26

Pages

11 - 15

Keywords

Animals, Humans, Malaria, Cerebral, Mice, Mice, Inbred C57BL, Mice, Inbred CBA, Plasmodium berghei