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Many insect viruses survive for long periods by occlusion within robust crystalline polyhedra composed primarily of a single polyhedrin protein. We show that two different virus families form polyhedra which, despite lack of sequence similarity in the virally encoded polyhedrin protein, have identical cell constants and a body-centered cubic lattice. It is almost inconceivable that this could have arisen by chance, suggesting that the crystal lattice has been preserved because it is particularly well-suited to its function of packaging and protecting viruses.

Original publication

DOI

10.1110/ps.051516405

Type

Journal article

Journal

Protein Sci

Publication Date

10/2005

Volume

14

Pages

2741 - 2743

Keywords

Animals, Cell Line, Inclusion Bodies, Viral, Insect Viruses, Intranuclear Inclusion Bodies, Moths, Powder Diffraction, Viral Structural Proteins