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Double-stranded RNA (dsRNA) viruses conceal their genome from the host to avoid triggering unfavorable cellular responses. The crystal structure of the core of one such virus, bluetongue virus, reveals an outer surface festooned with dsRNA. This may represent a deliberate strategy to sequester dsRNA released from damaged particles to prevent host cell shutoff.

Original publication

DOI

10.1128/jvi.76.18.9533-9536.2002

Type

Journal article

Journal

J Virol

Publication Date

09/2002

Volume

76

Pages

9533 - 9536

Keywords

Binding Sites, Bluetongue virus, Crystallography, X-Ray, Humans, Models, Molecular, Protein Conformation, RNA, Double-Stranded, RNA, Viral, Viral Core Proteins, X-Ray Diffraction