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Eukaryotic organisms cap the 5' ends of their messenger RNAs by a series of four chemical reactions. Some viruses achieve this using a single molecule; the crystal structure of such an enzyme from bluetongue virus reveals an elongated modular architecture that provides a scaffold for an assemblage of active sites, two contributed by a domain of novel structure.

Original publication

DOI

10.1038/nsmb1225

Type

Journal article

Journal

Nat Struct Mol Biol

Publication Date

05/2007

Volume

14

Pages

449 - 451

Keywords

Acid Anhydride Hydrolases, Binding Sites, Bluetongue virus, Crystallography, X-Ray, Methyltransferases, Protein Conformation, RNA Caps, RNA Nucleotidyltransferases, RNA, Viral