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Recent large--scale association studies, both of genome-wide and candidate gene design, have revealed several single-nucleotide polymorphisms (SNPs) which are significantly associated with risk of developing breast cancer. As both breast and endometrial cancers are considered to be hormonally driven and share multiple risk factors, we investigated whether breast cancer risk alleles are also associated with endometrial cancer risk. We genotyped nine breast cancer risk SNPs in up to 4188 endometrial cases and 11,928 controls, from between three and seven Caucasian populations. None of the tested SNPs showed significant evidence of association with risk of endometrial cancer.

Original publication

DOI

10.1093/carcin/bgr214

Type

Journal article

Journal

Carcinogenesis

Publication Date

12/2011

Volume

32

Pages

1862 - 1866

Keywords

Adolescent, Adult, Aged, Breast Neoplasms, Case-Control Studies, Endometrial Neoplasms, Female, Genetic Predisposition to Disease, Humans, Middle Aged, Polymorphism, Single Nucleotide, Young Adult