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Genetic variation in populations can result in variation in levels of gene expression but the extent to which this occurs has been unclear. In this article, recent studies of allele-specific expression among autosomal non-imprinted genes are reviewed. These new data provide evidence that differential expression is relatively common and that allelic differences are heritable and can be highly context specific.

Original publication

DOI

10.1016/j.tig.2004.01.001

Type

Journal article

Journal

Trends Genet

Publication Date

03/2004

Volume

20

Pages

113 - 116

Keywords

Alleles, Gene Expression Regulation, Genetic Variation, Genome, Human, Genomic Imprinting, Humans