Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

CLEC-2 is a C-type lectin-like molecule that has recently been identified as a receptor on the surface of platelets. Ligand binding by CLEC-2 promotes phosphorylation of a tyrosine in the cytoplasmic domain YXXL motif of CLEC-2 by Src kinases and further downstream signalling events trigger platelet activation and aggregation. The snake venom protein rhodocytin and the endogenous protein podoplanin have been identified as ligands. The structures of CLEC-2 and rhodocytin suggest that ligand binding could cluster CLEC-2 molecules at the platelet surface, so initiating signalling. CLEC-2 is a promising target for therapeutic strategies to inhibit platelet activity in thrombotic vascular disease.

Original publication

DOI

10.1016/j.coph.2008.11.001

Type

Journal article

Journal

Curr Opin Pharmacol

Publication Date

04/2009

Volume

9

Pages

90 - 95

Keywords

Animals, Blood Platelets, Drug Delivery Systems, Humans, Lectins, C-Type, Membrane Glycoproteins, Models, Molecular, Platelet Activation, Thrombosis, Viper Venoms