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Plasma antimalarial activity following oral artesunate or dihydroartemisinin (DHA) treatment was measured by a bioassay in 18 patients with uncomplicated falciparum malaria. The mean antimalarial activity in terms of the bioavailability of DHA relative to that of artesunate did not differ significantly from 1, suggesting that DHA can be formulated to be an acceptable oral alternative to artesunate.

Original publication

DOI

10.1128/aac.46.4.1125-1127.2002

Type

Journal article

Journal

Antimicrob Agents Chemother

Publication Date

04/2002

Volume

46

Pages

1125 - 1127

Keywords

Acute Disease, Adolescent, Adult, Aged, Antimalarials, Area Under Curve, Artemisinins, Artesunate, Biological Availability, Chromatography, High Pressure Liquid, Cross-Over Studies, Double-Blind Method, Female, Half-Life, Humans, Malaria, Falciparum, Male, Middle Aged, Sesquiterpenes, Spectrophotometry, Ultraviolet, Vietnam