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Antimycobacterial T cell reactivity at different stages of HIV infection was investigated. Subjects were screened with purified protein derivative (PPD), early secreted antigenic target (ESAT)-6, and culture filtrate protein (CFP)-10 antigens for interferon (IFN)-gamma-producing effector T cell responses by direct ex vivo enzyme-linked immunospot (ELISpot) assay. The proportion of responders to PPD tuberculin decreased with a reduction in CD4 T cell count, whereas the proportion of responder to ESAT-6 and CFP-10 did not. The main sources of IFN-gamma secretion were CD4 cells, and the relative responses to ESAT-6 and CFP-10 significantly increased in HIV-infected patients with decreasing CD4 cell count. This may reflect early signs of reactivation, reinfection, or a restricted, inefficient immune response to Mycobacterium tuberculosis.

Original publication

DOI

10.1086/524685

Type

Journal article

Journal

J Infect Dis

Publication Date

15/01/2008

Volume

197

Pages

295 - 299

Keywords

AIDS-Related Opportunistic Infections, Antigens, Bacterial, Bacterial Proteins, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes, Enzyme-Linked Immunosorbent Assay, HIV Infections, HIV-1, HIV-2, Humans, Immunosuppression, Interferon-gamma, Lymphocyte Activation, Mycobacterium tuberculosis, T-Lymphocytes, Tuberculin, Tuberculosis