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PURPOSE: We compared the pharmacokinetics of chloroquine in pregnant and nonpregnant women treated for Plasmodium vivax malaria. METHODS: Twelve pregnant women and 15 nonpregnant women of child-bearing age with acute P. vivax malaria were treated with 25 mg chloroquine base/kg over 3 days on the northwestern border of Thailand. Blood concentrations of chloroquine and desethylchloroquine were measured using hydrophilic interaction liquid chromatography coupled with fluorescence detection. Twenty-five women completed the pharmacokinetic study. RESULTS: Although increasing gestational age was associated with reduced chloroquine AUC0-->infinity, there was no significant difference overall in the pharmacokinetics of chloroquine between pregnant and nonpregnant women. Fever was associated with lower chloroquine AUC0-->infinity values. Desethylchloroquine area under the curve (AUC) values were not significantly affected by pregnancy. CONCLUSIONS: Pregnancy did not significantly affect blood concentrations of chloroquine or its metabolite, desethylchloroquine, in women with P. vivax malaria.

Original publication

DOI

10.1007/s00228-008-0500-z

Type

Journal article

Journal

Eur J Clin Pharmacol

Publication Date

10/2008

Volume

64

Pages

987 - 992

Keywords

Acute Disease, Adolescent, Adult, Animals, Antimalarials, Area Under Curve, Chloroquine, Female, Humans, Malaria, Vivax, Plasmodium vivax, Pregnancy, Pregnancy Complications, Parasitic, Pregnancy Outcome, Pregnancy Trimester, Second, Pregnancy Trimester, Third, Retrospective Studies, Thailand, Young Adult