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The metabolism of the third component of complement (C3) has been investigated in four patients with ulcerative colitis, three patients with Crohn's disease and seven control subjects, using radioiodinated C3 prepared from fresh human plasma. Both the fractional catabolic rate and synthesis rate of C3 were increased in the patients with inflammatory bowel disease, although the serum-C3 levels were normal or raised. The results suggest that complement activation may play a role in the pathogenesis of mucosal inflammation in these diseases.

Type

Journal article

Journal

Clin Exp Immunol

Publication Date

06/1977

Volume

28

Pages

490 - 495

Keywords

Adolescent, Adult, Colitis, Ulcerative, Complement C3, Complement System Proteins, Crohn Disease, Female, Humans, Male, Metabolic Clearance Rate, Middle Aged, Serum Albumin