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HIV-specific cytotoxic T lymphocytes (CTLs) play an important role in the immune response to HIV infection. Long-term nonprogressors (LTNPs) or slow progressors (SPs) in HIV infection may make qualitatively different CTL responses compared to those generated by seropositive individuals who progress to disease at a faster rate. The class I molecule HLA-B*57 has been identified as one restriction element overrepresented in SP groups studied, and, together with the closely related molecule HLA-B*58, occurs commonly in ethnic groups where HIV is most prevalent. In this study, we have identified five new HLA-B*57-restricted CTL epitopes recognized by SP donors, one of which is also HLA-B*5801 restricted. These HLA-B*57-restricted responses represent the dominant HIV-specific CTL response in each of the SP donors tested. These and other such epitopes may be an important component in future vaccine design.

Original publication

DOI

10.1089/aid.1996.12.1691

Type

Journal article

Journal

AIDS Res Hum Retroviruses

Publication Date

10/12/1996

Volume

12

Pages

1691 - 1698

Keywords

Amino Acid Sequence, Blood Donors, Disease Progression, Epitopes, T-Lymphocyte, Ethnic Groups, HIV Antigens, HIV Infections, HIV-1, HLA-B Antigens, Humans, Immunodominant Epitopes, Molecular Sequence Data, T-Lymphocytes, Cytotoxic