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An experimental colitis in rabbits is described, following the intravenous injection of preformed immune complexes of human serum albumin (HSA) and anti-HSA into non-sensitised rabbits. Tissue damage was localised to the colon by the Auer technique of inducing local non-specific inflammation, by the rectal instillation of dilute formalin. Formalin alone gave transient changes that reverted to normal within 24 hours. In rabbits given intravenous immune complexes formed in antigen-excess, a severe colitis was initiated, with histological features including mucosal ulceration, mixed inflammatory cell infiltration in the lamina propria, and crypt abscess formation. It is possible that immune-complex damage may be one of the pathogenic mechanisms involved in human ulcerative colitis.

Type

Journal article

Journal

Gut

Publication Date

03/1978

Volume

19

Pages

225 - 232

Keywords

Animals, Antigen-Antibody Complex, Centrifugation, Density Gradient, Colitis, Ulcerative, Female, Formaldehyde, Inflammation, Male, Rabbits, Rectum