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Cell-mediated immunity to a synthetic peptide, which has a 12-residue sequence from A-gliadin analogous to part of an early-region protein (Elb) from adenovirus 12, was investigated in patients with coeliac disease, healthy subjects, and disease controls by means of an indirect leucocyte-migration-inhibition assay. Patients with coeliac disease being treated with a gluten-free diet showed a significantly greater response than healthy subjects (p less than 0.001) or patients with inflammatory bowel disease. This cellular immune response was dependent on antigen concentration and was not present in untreated coeliac patients.

Type

Journal article

Journal

Lancet

Publication Date

18/04/1987

Volume

1

Pages

884 - 886

Keywords

Adenovirus Early Proteins, Adult, Aged, Celiac Disease, Cell Migration Inhibition, Dose-Response Relationship, Immunologic, Female, Gliadin, HLA Antigens, Humans, Leukocytes, Male, Middle Aged, Oncogene Proteins, Viral, Peptide Fragments, Plant Proteins