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Medical records of patients with ulcerative colitis (n = 858), Crohn's disease (n = 378) and coeliac disease (n = 148) were examined to determine the prevalence of associated autoimmune disorders. Of outpatient controls (n = 300), 2 per cent had at least one autoimmune disorder, compared to 7 per cent with ulcerative colitis, 2 per cent with Crohn's disease and 6 per cent with coeliac disease. Inclusion of primary sclerosing cholangitis with the autoimmune disorders increased the overall prevalence in ulcerative colitis to over 9 per cent. The results provide further indirect evidence of involvement of autoimmune mechanisms in the pathogenesis of ulcerative colitis.

Type

Journal article

Journal

Q J Med

Publication Date

09/1989

Volume

72

Pages

835 - 840

Keywords

Adult, Anemia, Hemolytic, Autoimmune, Autoimmune Diseases, Celiac Disease, Cholangitis, Sclerosing, Colitis, Ulcerative, Crohn Disease, Female, Humans, Male, Middle Aged, Prevalence