Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Epithelial histocompatibility locus antigen (HLA) class II expression was studied to evaluate its induction by mucosal mononuclear cells in inflammatory bowel disease and to characterise the responsible cytokine. Unstimulated cells of the HT-29 epithelial cell line did not produce class II molecules. After being stimulated with the mitogenic lectin phytohaemagglutinin mucosal mononuclear cells released a cytokine that induced epithelial HLA-DR expression. The cytokine had the physicochemical and immunological characteristics of interferon-gamma, and no additional cytokines were detected.

Type

Journal article

Journal

Gut

Publication Date

03/1992

Volume

33

Pages

315 - 319

Keywords

Adolescent, Adult, Aged, Cell Line, Cells, Cultured, Colonic Neoplasms, Cytokines, Enterocolitis, Enzyme-Linked Immunosorbent Assay, Epithelium, HLA-DR Antigens, Humans, Immunoenzyme Techniques, Interferon-gamma, Intestinal Mucosa, Middle Aged