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This study compares the incidence rates of histologically confirmed gastric carcinoma in Oxfordshire in two five year periods (1960-64, 1984-88). Data were available for 215 patients in the first period, and 200 in the second. The overall incidence fell from 18/100,000 to 15/100,000 but when analysed for site, the incidence of antral tumours fell from 10 to 4.5/100,000. In contrast, there was an increase from 2.8 to 5.2/100,000 of tumours of the cardia. These changes were more pronounced in men. There was a marked association between smoking and tumours of the cardia (relative risk 4.5). Helicobacter pylori was associated with 37.5% of tumours in the 1960s series compared with 25% in the later series. The changing patterns of incidence of gastric carcinoma may, in part, be related to changes in smoking habits and perhaps a change in incidence of H pylori infection.

Type

Journal article

Journal

Gut

Publication Date

10/1992

Volume

33

Pages

1312 - 1317

Keywords

Age Factors, Aged, Cardia, England, Female, Helicobacter Infections, Helicobacter pylori, Humans, Incidence, Intestinal Neoplasms, Male, Pyloric Antrum, Risk Factors, Sex Factors, Smoking, Stomach Neoplasms