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A double-blind, randomised, controlled trial was conducted in 248 British infants to assess the immunogenicity and tolerability of three doses of a meningococcal group C/CRM (197) conjugate vaccine (Lederle Laboratories, USA) given at 2, 3 and 4 months. Control children received three doses of Hepatitis B vaccine (Engerix B(R); SmithKline Beecham). At 5 months of age, 100% of children receiving the conjugate vaccine had specific immunoglobulin G concentrations >2.0 microg/ml (n=116) compared with only 4% of control children (n=121). Those receiving the conjugate also had 2.5- and 1.6-fold higher geometric mean concentrations of PRP and diphtheria antibodies, respectively. The vaccine was well tolerated.

Type

Journal article

Journal

Vaccine

Publication Date

08/12/2000

Volume

19

Pages

1232 - 1238

Keywords

Antibodies, Bacterial, Blood Bactericidal Activity, Double-Blind Method, Enzyme-Linked Immunosorbent Assay, Female, Humans, Infant, Male, Meningococcal Vaccines, Neisseria meningitidis, Vaccines, Conjugate