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AIDS‐associated Cryptococcus neoformans and Penicillium marneffei coinfection has not been adequately studied and poses unique therapeutic challenges in resource‐limited settings. Itraconazole poorly penetrates the central nervous system, whereas fluconazole has poor activity against P. marneffei. We prospectively report management of 1 patient and retrospectively review 7 coinfection cases from Vietnam.

Original publication

DOI

10.1086/656685

Type

Journal article

Journal

Clin Infect Dis

Publication Date

01/11/2010

Volume

51

Pages

e65 - e68

Keywords

AIDS-Related Opportunistic Infections, Adult, Antifungal Agents, Cryptococcus neoformans, Developing Countries, Diagnosis, Differential, Fluconazole, Humans, Itraconazole, Male, Mycoses, Penicillium, Prospective Studies, Retrospective Studies, Vietnam