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OBJECTIVES: To compare the efficacy of moxifloxacin, gatifloxacin and ciprofloxacin for the post-exposure prophylaxis and treatment of experimental Burkholderia pseudomallei infection. The presence of persistent infection in treated animals and the rate of relapse following dexamethasone treatment were also investigated. METHODS: BALB/c mice were inoculated subcutaneously with 1.75 x 10(6) cfu of B. pseudomallei strain 576. Gatifloxacin, moxifloxacin and ciprofloxacin (100 mg/kg) were given orally at 12 hourly intervals for 14 days starting at 6 h, 7 days or 12 days post-challenge. Control mice did not receive antibiotic therapy. RESULTS: No regimen gave 100% protection. Prophylaxis was most effective when started 6 h post-challenge, with survival rates at 42 days for ciprofloxacin, gatifloxacin and moxifloxacin being 58%, 75% and 75%, respectively. For treatment started at day 7 post-challenge, survival rates were 17%, 11% and 44%, respectively. When antibiotic treatment was delayed until day 12 post-challenge, survival rates fell to 21%, 17% and 28%, respectively. Following dexamethasone treatment of survivors at 42 days post-challenge, relapses occurred in all treatment groups. CONCLUSIONS: Fluoroquinolones do not provide good post-exposure protection against infection with B. pseudomallei. The newer agents moxifloxacin and gatifloxacin are not significantly better than ciprofloxacin for this purpose.

Original publication

DOI

10.1093/jac/dki039

Type

Journal article

Journal

The Journal of antimicrobial chemotherapy

Publication Date

04/2005

Volume

55

Pages

523 - 527

Addresses

Biomedical Sciences, Dstl Porton Down, Salisbury SP4 OJQ, UK. jasteward@dstl.gov.uk

Keywords

Animals, Mice, Inbred BALB C, Mice, Melioidosis, Aza Compounds, Quinolines, Fluoroquinolones, Ciprofloxacin, Dexamethasone, Glucocorticoids, Anti-Bacterial Agents, Drug Administration Schedule, Female