Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

The development of autoimmune type 1 diabetes mellitus in man and the nonobese diabetic (NOD) mouse is greatly influenced by a gene linked to the MHC. Although homozygosity at the NOD MHC is required for a high prevalence of disease, during backcross studies we have found a small number of diabetic H-2nod/b MHC heterozygotes. These diabetic heterozygotes could either represent a crossover event between the MHC and a putative MHC-linked diabetogenic gene or, alternatively, they could indicate that there is a dominant MHC-linked diabetic gene that has low penetrance in the heterozygous state. Pedigree analysis of a diabetic H-2nod/b MHC heterozygote favors the latter hypothesis.

Type

Journal article

Journal

Journal of immunology (Baltimore, Md. : 1950)

Publication Date

02/1989

Volume

142

Pages

781 - 784

Addresses

Department of Immunology Research, Merck Sharp & Dohme Research Laboratories, Rahway, NJ 07065.

Keywords

Islets of Langerhans, Animals, Mice, Inbred Strains, Mice, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 1, Autoimmune Diseases, H-2 Antigens, Crosses, Genetic, Pedigree, Heterozygote, Homozygote, Female