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The development of autoimmune type 1 diabetes mellitus in man and the nonobese diabetic (NOD) mouse is greatly influenced by a gene linked to the MHC. Although homozygosity at the NOD MHC is required for a high prevalence of disease, during backcross studies we have found a small number of diabetic H-2nod/b MHC heterozygotes. These diabetic heterozygotes could either represent a crossover event between the MHC and a putative MHC-linked diabetogenic gene or, alternatively, they could indicate that there is a dominant MHC-linked diabetic gene that has low penetrance in the heterozygous state. Pedigree analysis of a diabetic H-2nod/b MHC heterozygote favors the latter hypothesis.

Type

Journal article

Journal

Journal of immunology (Baltimore, Md. : 1950)

Publication Date

02/1989

Volume

142

Pages

781 - 784

Addresses

Department of Immunology Research, Merck Sharp & Dohme Research Laboratories, Rahway, NJ 07065.

Keywords

Islets of Langerhans, Animals, Mice, Inbred Strains, Mice, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 1, Autoimmune Diseases, H-2 Antigens, Crosses, Genetic, Pedigree, Heterozygote, Homozygote, Female