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Major histocompatabilty (MHC) proteins rely heavily on peptide backbone recognition for ligation. Nonetheless, modifications to the polyamide backbone of a tetrapeptide ligand can be made without abrogating binding.

Original publication

DOI

10.1016/s0960-894x(99)00333-9

Type

Journal article

Journal

Bioorganic & medicinal chemistry letters

Publication Date

07/1999

Volume

9

Pages

2109 - 2114

Addresses

Department of Basic Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA.

Keywords

Lactams, Peptides, Phosphoproteins, Transcription Factors, Hemagglutinins, Histocompatibility Antigens Class II, HLA-DR1 Antigen, Ligands, Inhibitory Concentration 50, Binding Sites, Molecular Mimicry, Molecular Structure, Structure-Activity Relationship