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Plasmodium species ex vivo sensitivity assay protocols differ in the requirement for leukocyte removal before culturing. This study shows that the presence of leukocytes significantly increases the 50% inhibitory concentration (IC₅₀) of P. vivax and P. falciparum to artesunate and chloroquine relative to results with the paired leukocyte-free treatment. Although leukocyte removal is not an essential requirement for the conduct of ex vivo assays, its use has important implications for the interpretation of temporal and spatial antimalarial sensitivity data.

Original publication

DOI

10.1128/AAC.01103-10

Type

Journal article

Journal

Antimicrob Agents Chemother

Publication Date

03/2011

Volume

55

Pages

1300 - 1304

Keywords

Antimalarials, Artemisinins, Artesunate, Chloroquine, Humans, Inhibitory Concentration 50, Leukocytes, Parasitic Sensitivity Tests, Plasmodium falciparum, Plasmodium vivax