Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Background:Tuberculosis (TB) is a preventable and treatable chronic disease. Afghanistan is among the high-TB-burden countries. The aim of this study is to find the determinants of treatment failure among TB patients in Kandahar City, Afghanistan. Methods:This was a retrospective cohort study conducted in Kandahar City during a period of 5 years (August 2014-July 2019). For data analysis; descriptive statistics, Chi-square test, and logistic regression were used. Results:Among 1416 TB patients, 894/1416 (63.1%) had pulmonary TB (PTB), whereas 522/1416 (36.9%) had extrapulmonary TB (EPTB). Mean age in these patients was 34.7 years while most of them were females in PTB (530/894 [59.3%]) and EPTB (340/522 [65.1%]) patients. Sputum smear was positive in 618/860 (71.9%) and 16/404 (4%) of PTB and EPTB patients, respectively. TB treatment failure was more in PTB (56/894 [6.3%]) than EPTB (4/522 [0.8%]). Chi-square test of TB cases showed that statistically significant determinants that may cause the treatment failure were re-treatment cases (crude odds ratio [COR] 7.7, P < 0.001), absence of fever (COR 5.2, P < 0.001), absence of cough (COR 1.7, P = 0.004), living in rural areas (COR 1.4, P = 0.035), and no weight loss (COR 1.3, P = 0.033). Binary logistic regression of the statistically significant variables revealed only absence of fever (adjusted odds ratio 6.0, P < 0.001) as the risk factor for treatment failure in TB patients. Conclusion:TB is still a major threat for Kandahar City. Low treatment success rate and increased number of defaulted cases are the major threats.

Original publication

DOI

10.4103/ijmy.ijmy_142_19

Type

Journal article

Journal

International journal of mycobacteriology

Publication Date

10/2019

Volume

8

Pages

359 - 365

Addresses

Department of Paediatrics, Faculty of Medicine, Kandahar University, Kandahar, Afghanistan.

Keywords

Sputum, Humans, Tuberculosis, Tuberculosis, Pulmonary, Antitubercular Agents, Treatment Outcome, Treatment Failure, Logistic Models, Odds Ratio, Risk Factors, Retrospective Studies, Adolescent, Adult, Aged, Middle Aged, Afghanistan, Female, Male, Young Adult