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A 15% aminosidine sulphate (AS)/10% urea/white soft paraffin (WSP) ointment cured all Leishmania major lesions on Balb/C mice following topical application for 10 d. Some relapses were observed 10 weeks after treatment. AS alone in WSP ointment was also highly effective. The ointment containing urea was non-irritant to mice, whereas ointments containing quaternary ammonium compounds were irritant. The 15% AS/10% urea/WSP ointment was not effective in the treatment of L. mexicana or L. panamensis lesions on Balb/C mice, no cure being observed.

Original publication

DOI

10.1016/0035-9203(94)90307-7

Type

Journal article

Journal

Transactions of the Royal Society of Tropical Medicine and Hygiene

Publication Date

03/1994

Volume

88

Pages

223 - 225

Addresses

Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, UK.

Keywords

Animals, Mice, Inbred BALB C, Mice, Leishmaniasis, Cutaneous, Paromomycin, Ointments, Random Allocation, Female