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Ex vivo conversion of the anti-influenza drug oseltamivir to its active metabolite can be inhibited by the esterase inhibitor dichlorvos or by using commercial fluoride-oxalate tubes. Oseltamivir and its active metabolite remain intact in plasma samples during a proposed virus heat inactivation step: incubation at 60 degrees C for 45 min.

Original publication

DOI

10.1128/AAC.01534-06

Type

Journal article

Journal

Antimicrob Agents Chemother

Publication Date

05/2007

Volume

51

Pages

1835 - 1836

Keywords

Antiviral Agents, Blood Specimen Collection, Drug Stability, Humans, Oseltamivir, Temperature