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We have investigated the in vitro susceptibility of the human malaria parasite Plasmodium falciparum to killing by nitric oxide and related molecules. A saturated solution of nitric oxide did not inhibit parasite growth, but two oxidation products of nitric oxide (nitrite and nitrate ions) were toxic to the parasite in millimolar concentrations. Nitrosothiol derivatives of cysteine and glutathione were found to be about a thousand times more active (50% growth inhibitory concentration, approximately 40 microM) than nitrite.

Type

Journal article

Journal

Infection and immunity

Publication Date

09/1991

Volume

59

Pages

3280 - 3283

Addresses

Division of Cell Biology, John Curtin School of Medical Research, Canberra, A.C.T., Australia.

Keywords

Animals, Plasmodium falciparum, Nitric Oxide, Nitroso Compounds, Colony Count, Microbial, Lethal Dose 50