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Metallothionein (MT) gene transcription is regulated in a developmental and tissue-specific manner by metal ions and other agents. We examined MT expression in the human promyelocytic leukemia cell line HL-60 during differentiation along macrophage and neutrophil lineages. All HL-60 phenotypes showed similar basal levels of MT RNA with significant induction following exposure to Cd2+ but not activators of PKC. MT RNA did not correlate with growth state or with known levels of PKC activity, thus our data do not support a role for MT in HL-60 differentiation or for PKC in MT expression.

Type

Journal article

Journal

FEBS Lett

Publication Date

05/12/1988

Volume

241

Pages

159 - 163

Keywords

Amino Acid Sequence, Base Sequence, Cadmium, Calcimycin, Calcitriol, Cell Differentiation, Cell Line, Enzyme Activation, Humans, Leukemia, Promyelocytic, Acute, Metallothionein, Molecular Sequence Data, Oligonucleotide Probes, Protein Kinase C, RNA, Messenger, Tetradecanoylphorbol Acetate