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In partnership with the Oxford University Hospitals NHS Trust the Nuffield Department of Clinical Medicine is committed to maintaining the highest standards of clinical care. More than 30 senior staff hold Honorary Contracts with ORHT and an equal number of full-time or maximum part-time NHS Consultant Staff hold Honorary University contracts with the Department. Several senior staff within the Department, including the Head of Department, contribute to the on-call rota for Oxford's Acute General Medicine service, whilst many other staff are active in speciality medicine including Clinical Immunology, Dermatology, Gastroenterology, Genito-Urinary Medicine, Geratology, Infectious Diseases, Intensive Care Medicine, Musculo-skeletal Medicine, Palliative Care, Radiology, Renal Medicine, Respiratory Medicine, and Tropical Medicine.

The Oxford University Hospitals NHS Trust is one of the largest NHS teaching trusts in the country. It provides a wide range of general and specialist clinical services and is a base for medical education, training and research.

In partnership with the University, the ORHT was selected in 2006 to host one of the NIHR's five comprehensive Biomedical Research Centres with a budget in excess of £11M per annum. Several NDM staff are theme leaders within the O2 partnership BMRC.